Marijuana erectile dysfunction refers to erection difficulty linked to short-term or long-term cannabis use — usually caused by changes in blood flow, dopamine sensitivity, arousal conditioning, and anxiety regulation. How Marijuana Affects the Body and Brain Marijuana contains more than 100 cannabinoids, the most active being tetrahydrocannabinol (THC)  and cannabidiol (CBD) . These compounds interact with the body’s endocannabinoid system , a network of receptors that regul